About the Lab
The Farrar group's research program is focused on the development of novel Magnetic Resonance molecular imaging contrast agents and methods and on the development of innovative Magnetic Resonance Imaging (MRI) methods for characterizing vascular structure and function. The tools being developed in our lab are being applied to studies of a wide range of diseases, including Alzheimer's disease, cancer, fibrosis, and stroke. Our recent molecular imaging efforts have been focused on the development of chemical exchange saturation transfer (CEST) MRI reporter genes for imaging oncolytic virotherapy, collagen targeted MRI contrast agents for imaging liver fibrosis, and RNA aptamer contrast agents targeted against amyloid-β. Our vascular imaging efforts have focused on developing MRI methods for measuring average vessel caliber, vascular reactivity, and transendothelial water exchange and their application to studies of novel brain tumor therapies and stroke.